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Description

Neutrophil and PBMC gene expression data from Job's Syndrome - GSE8507 - PBMC

Purpose

Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal dominant. The aim of the study if to identify a specific defect or gene of interest.

Experimental Design

Polymorphonuclear leukocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated from whole blood from patients with Job's syndrome and healthy control subjects. PMNs and PBMCs were incubated with or without IgG- and C3bi-coated latex beads for 3 and 6 hours.

Experimental Variables

IgG- and C3bi-coated latex beads, time

Controls

5 healthy controls

Methods

PMNs and PBMCs were isolated from venous blood of each participant in accordance with a protocol approved by the Institutional Review Board for Human Subjects, National Institute of Allergy and Infectious Diseases.

Platform Affymetrix HG-U133_Plus_2
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Signal Data File

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Additional Files:

(Uploaded through the Files tab in the Annotation Tool)

GSE8507_v1.csv

GSE8507_v3.1.csv

GSE8507_v3.1.csv

GSE8507_v3.1.csv

GSE8507_v3.1.csv

GSE8507_v3.csv

GSE8507_v3.csv

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