Transcriptional profiling of egg allergy and relationship to disease phenotype - GSE88796

To characterize the of gene expression of PBMCs from egg allergic and clinically tolerant subjects.

PBMCs were obtained from egg allergic children, some of whom are baked egg responsive (BER) and some are baked egg tolerant (BET), as well as food allergic controls (AC) who were clinically tolerant to egg. PBMCs were stimulated with egg antigen, gene transcription measured by microarray after 24 hours, and cytokine secretion by multiplex assay after 5 day incubation.

Egg atigen

Food allergic controls

In lumi, the data are transformed (variance-stabilizing transformation (VST)) and normalized (robust spline normalization (RSN)), resulting in log-transformed normalized data.