Gene expression patterns in house dust mite stimulated CD4 T cells and IgG to IgE ratios - GSE70760
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| Description | Gene expression patterns in house dust mite stimulated CD4 T cells and IgG to IgE ratios - GSE70760 |
| Purpose | Distinguishing benign from pathologic TH2 immunity in atopic children |
| Hypothesis | HDM generate a distinct transcriptomic signature in CD4 T cells. |
| Experimental Design | The study design consisted of 45 subjects and two conditions (medium control, HDM stimulation). |
| Experimental Variables | Stimulation with HDM |
| Controls | Stimulation with AIM-V medium alone. |
| Methods | PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, CD4 T cells were isolated using immunomagnetic separation. Gene expression was profiled on microarrays. |
| Additional Information | The microarray data was preprocessed in R employing the RMA algorithm and a custom chip description file (hugene10st_Hs_ENTREZG, v19). ComBat was used to adjust the data for batch effects. |
| Platform | Affymetrix HuGene-1_0-st (hugene10st_Hs_ENT) v1 |
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