The effect of a dexamethasone and a FK506 on the induction of chemokines in human mast cells - GSE15174
The objective of this study was to comprehensively investigate FceRI-mediated chemokine induction in human mast cells and the effect of a corticosteroid (dexamethasone) and a calcineurin inhibitor (FK506).
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Human peripheral blood-derived mast cells were stimulated with anti-IgE antibody in the presence of dexamethasone or FK506. Gene expression profiles were evaluated using GeneChip Human Genome U133 plus 2.0 probe arrays (Affymetrix).
Stimulation with anti-IgE antibody in the presence of dexamethasone or FK506.
DMSO
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| Sample ID | agent | Cell type |
|---|---|---|
| GSM378805 | DMSO | peripheral blood-derived mast cells |
| GSM378807 | aIgE | peripheral blood-derived mast cells |
| GSM378808 | DEX_aIgE | peripheral blood-derived mast cells |
| GSM378809 | FK506_aIgE | peripheral blood-derived mast cells |
| GSM378810 | DEX_ FK506_aIgE | peripheral blood-derived mast cells |
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| Sample ID | Agent | Cell type |
|---|---|---|
| GSM378805 | DMSO |
peripheral blood-derived mast cells |
| GSM378807 | aIgE |
peripheral blood-derived mast cells |
| GSM378808 | DEX_aIgE |
peripheral blood-derived mast cells |
| GSM378809 | FK506_aIgE |
peripheral blood-derived mast cells |
| GSM378810 | DEX_ FK506_aIgE |
peripheral blood-derived mast cells |
| Name | ||
|---|---|---|
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