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Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1) - GSE44956

Purpose

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Hypothesis

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Experimental Design

Peripheral blood mononuclear cells (PBMCs) were collected from 8 high responders (HR) and 8 low responders (LR) to GC treatment. PBMCs were challenged with diluent, grass pollen extract (ALK-Abelló A/S; 100 ?g/mL) as well as grass pollen extract plus glucocorticoids (100ug/mL) for one week.

Experimental Variables

diluent, grass pollen extract (ALK-Abelló A/S; 100 ?g/mL) as well as grass pollen extract plus glucocorticoids (100ug/mL)

Controls

8 low responders

Methods

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Additional Information

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Microarray
Agilent SurePrint G3 Human GE Probe Name v1
48 Samples Loaded: 48
Human (Homo sapiens)
PBMC , T cells (CD4+)
Rhinitis
PBMCs were collected from 8 high responders (HR) and 8 low responders (LR) to GC treatment and were challenged with diluent, grass pollen extract (ALK-Abelló A/S; 100 ?g/mL) as well as grass pollen extract plus glucocorticoids (100ug/mL) for one week.
Total CD4+ T cells were enriched by MACS negative sorting. Total RNA was extracted using a miRNeasy Mini Kit (Qiagen, Valencia, CA, USA).
Sample Set Spreadsheet
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Samples Preview
Sample ID tissue group Cell type treatment patient
GSM1094383 whole blood high_diluent CD4+ T cells diluent 9
GSM1094384 whole blood low_allergen CD4+ T cells allergen 10
GSM1094385 whole blood high_allergen_GCR CD4+ T cells allergen_GCR 11
GSM1094386 whole blood high_allergen CD4+ T cells allergen 13
GSM1094387 whole blood high_allergen_GCR CD4+ T cells allergen_GCR 12
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File
GSE44956_v1.csv
Sample Set Spreadsheet
GSE44956_v1.csv
Sample Set Spreadsheet
Quantile Normalized
Raw Signal
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Sample ID Tissue Group Cell type Treatment Patient Sample Title Disease Status Gc responder type
GSM1094383
whole blood
high_diluent
CD4+ T cells
diluent
9
HR_P9_D
seasonal allergic rhinitis (SAR)
high
GSM1094384
whole blood
low_allergen
CD4+ T cells
allergen
10
LR_P10_A
seasonal allergic rhinitis (SAR)
low
GSM1094385
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
11
HR_P11_T
seasonal allergic rhinitis (SAR)
high
GSM1094386
whole blood
high_allergen
CD4+ T cells
allergen
13
HR_P13_A
seasonal allergic rhinitis (SAR)
high
GSM1094387
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
12
HR_P12_T
seasonal allergic rhinitis (SAR)
high
GSM1094388
whole blood
low_diluent
CD4+ T cells
diluent
14
LR_P14_D
seasonal allergic rhinitis (SAR)
low
GSM1094389
whole blood
high_allergen
CD4+ T cells
allergen
16
HR_P16_A
seasonal allergic rhinitis (SAR)
high
GSM1094390
whole blood
high_diluent
CD4+ T cells
diluent
15
HR_P15_D
seasonal allergic rhinitis (SAR)
high
GSM1094391
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
10
LR_P10_T
seasonal allergic rhinitis (SAR)
low
GSM1094392
whole blood
high_diluent
CD4+ T cells
diluent
11
HR_P11_D
seasonal allergic rhinitis (SAR)
high
GSM1094393
whole blood
high_allergen
CD4+ T cells
allergen
12
HR_P12_A
seasonal allergic rhinitis (SAR)
high
GSM1094394
whole blood
high_diluent
CD4+ T cells
diluent
13
HR_P13_D
seasonal allergic rhinitis (SAR)
high
GSM1094395
whole blood
high_allergen
CD4+ T cells
allergen
15
HR_P15_A
seasonal allergic rhinitis (SAR)
high
GSM1094396
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
14
LR_P14_T
seasonal allergic rhinitis (SAR)
low
GSM1094397
whole blood
high_diluent
CD4+ T cells
diluent
16
HR_P16_D
seasonal allergic rhinitis (SAR)
high
GSM1094398
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
9
HR_P9_T
seasonal allergic rhinitis (SAR)
high
GSM1094399
whole blood
high_allergen
CD4+ T cells
allergen
9
HR_P9_A
seasonal allergic rhinitis (SAR)
high
GSM1094400
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
16
HR_P16_T
seasonal allergic rhinitis (SAR)
high
GSM1094401
whole blood
low_diluent
CD4+ T cells
diluent
10
LR_P10_D
seasonal allergic rhinitis (SAR)
low
GSM1094402
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
13
HR_P13_T
seasonal allergic rhinitis (SAR)
high
GSM1094403
whole blood
high_diluent
CD4+ T cells
diluent
12
HR_P12_D
seasonal allergic rhinitis (SAR)
high
GSM1094404
whole blood
low_allergen
CD4+ T cells
allergen
14
LR_P14_A
seasonal allergic rhinitis (SAR)
low
GSM1094405
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
15
HR_P15_T
seasonal allergic rhinitis (SAR)
high
GSM1094406
whole blood
high_allergen
CD4+ T cells
allergen
11
HR_P11_A
seasonal allergic rhinitis (SAR)
high
GSM1094407
whole blood
low_allergen
CD4+ T cells
allergen
1
LR_P1_A
seasonal allergic rhinitis (SAR)
low
GSM1094408
whole blood
low_diluent
CD4+ T cells
diluent
2
LR_P2_D
seasonal allergic rhinitis (SAR)
low
GSM1094409
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
3
LR_P3_T
seasonal allergic rhinitis (SAR)
low
GSM1094410
whole blood
low_diluent
CD4+ T cells
diluent
4
LR_P4_D
seasonal allergic rhinitis (SAR)
low
GSM1094411
whole blood
low_diluent
CD4+ T cells
diluent
1
LR_P1_D
seasonal allergic rhinitis (SAR)
low
GSM1094412
whole blood
low_allergen
CD4+ T cells
allergen
2
LR_P2_A
seasonal allergic rhinitis (SAR)
low
GSM1094413
whole blood
low_diluent
CD4+ T cells
diluent
3
LR_P3_D
seasonal allergic rhinitis (SAR)
low
GSM1094414
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
4
LR_P4_T
seasonal allergic rhinitis (SAR)
low
GSM1094415
whole blood
high_diluent
CD4+ T cells
diluent
5
HR_P5_D
seasonal allergic rhinitis (SAR)
high
GSM1094416
whole blood
high_allergen
CD4+ T cells
allergen
6
HR_P6_A
seasonal allergic rhinitis (SAR)
high
GSM1094417
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
5
HR_P5_T
seasonal allergic rhinitis (SAR)
high
GSM1094418
whole blood
low_allergen
CD4+ T cells
allergen
8
LR_P8_A
seasonal allergic rhinitis (SAR)
low
GSM1094419
whole blood
high_allergen
CD4+ T cells
allergen
5
HR_P5_A
seasonal allergic rhinitis (SAR)
high
GSM1094420
whole blood
high_diluent
CD4+ T cells
diluent
6
HR_P6_D
seasonal allergic rhinitis (SAR)
high
GSM1094421
whole blood
low_allergen
CD4+ T cells
allergen
7
LR_P7_A
seasonal allergic rhinitis (SAR)
low
GSM1094422
whole blood
high_allergen_GCR
CD4+ T cells
allergen_GCR
6
HR_P6_T
seasonal allergic rhinitis (SAR)
high
GSM1094423
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
1
LR_P1_T
seasonal allergic rhinitis (SAR)
low
GSM1094424
whole blood
low_diluent
CD4+ T cells
diluent
8
LR_P8_D
seasonal allergic rhinitis (SAR)
low
GSM1094425
whole blood
low_allergen
CD4+ T cells
allergen
3
LR_P3_A
seasonal allergic rhinitis (SAR)
low
GSM1094426
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
8
LR_P8_T
seasonal allergic rhinitis (SAR)
low
GSM1094427
whole blood
low_diluent
CD4+ T cells
diluent
7
LR_P7_D
seasonal allergic rhinitis (SAR)
low
GSM1094428
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
2
LR_P2_T
seasonal allergic rhinitis (SAR)
low
GSM1094429
whole blood
low_allergen_GCR
CD4+ T cells
allergen_GCR
7
LR_P7_T
seasonal allergic rhinitis (SAR)
low
GSM1094430
whole blood
low_allergen
CD4+ T cells
allergen
4
LR_P4_A
seasonal allergic rhinitis (SAR)
low

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